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Disseminated Coccidioidomycosis






Coccidioidomycosis is a systemic mycosis characterized by primary pulmonary infection that usually spontaneously. Subsequently, It can disseminate hematogenously and result in chronic, progressive, granulomatous infection in skin, lungs, bone, meninges.



Causes:

Spores inhaled, resulting in primary pulmonary infection that is asymptomatic or accompanied by symptoms of coryza. Failure to develop cell-mediated immunity is associated with disseminated infection and relapse after therapy.



Symptoms:

Symptoms include fever, joint pain, loss of appetite, weight loss, night sweats, skin lesions, and difficulty breathing. Also, in 30-50% of patients with disseminated coccidioidomycosis, the tissue coverings of the the brain and spinal cord become inflamed (meningitis).

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